Intermediates

Pharmabridge :Intermediates

Pharmaceutical intermediates are chemical compounds used during the synthesis of Active Pharmaceutical Ingredients (APIs). These intermediates play a crucial role in the production process, serving as building blocks that undergo further chemical reactions to form the final therapeutic compound. Their quality and purity are essential in ensuring the efficacy and safety of the resulting API. In the pharmaceutical industry, intermediates must meet stringent regulatory standards to ensure consistency and avoid contaminants. Pharmabridge helps bridge the gap in access to high-quality intermediates by promoting collaborations between manufacturers, regulatory bodies, and suppliers. By enhancing the supply chain and facilitating knowledge exchange, Pharmabridge enables pharmaceutical companies, particularly in developing regions, to produce cost-effective, high-quality medicines, ultimately improving global healthcare outcomes.

INTERMEDIATESA1:D16A76A1:D81
SR. NO. API INTERMEDIATES CAS NO
ONCOLOGY INTERMEDIATES
2 Etoposide Podophyllotoxin 50% 518-28-5
Podophyllotoxin 98% 518-28-5
4 de methyl epi Podophyllotoxin 6559-91-7
2 Imatinib Mesylate Imatinb Base 152459-95-5
4-[(4-Methylpiperazin-1- yl)methyl]benzoic acid dihydrochloride 106261-49-8
N-(5-Amino-2-methylphenyl)-4-(3- pyridyl)-2- pyrimidine amine 152460-10-1
3 Bortezomib N-[(1S)-2-[[(1R)-1-[(3as,4S,6S,7ar)- Hexahydro-3a,5,5-trimethyl-4,6-methano- 1,3,2-benzodioxaborol-2-yl]-3- methylbutyl]amino]-2-oxo-1- (phenylmethyl) ethyl]-2- pyrazinecarboxamide Bortezomib N-2 stage intermediate 205393-22-2
(R) –Boroleu-(+)-Pinanediol Trifluoroacetate 179324-87-9
N-(2-Pyrazinylcarbonyl)-L-phenylalanine 114457-94-2
N-1 Bortezomib
4 Gefitinib 7-Methoxy-6-(3-morpholinopropoxy)-3,4- dihydroquinazolin-4-one (N-1) 199327-61-2
5 Axitinib 6-Nitro-1H-indazole 7597-18-4
2-Mercapto-N-methylbenzamide 20054-45-9
9,9-Dimethyl-4,5- bis(diphenylphosphino)xanthene 161265-03-8
2-Vinyl pyridine
6 Gemcitabine 2′,2′-Difluoro-2′-deoxycytidine-3′,5′- dibenzoate (T9) 134790-39-9
7 Pazopanib N-(2-chloropyrimidin-4-yl)-N,2,3- trimethyl-2H-indazol-6-amine (N-1) 444731-75-3
8 Sunitinib 5-Fluoro-2-Oxindole 56341-41-4
5-formyl-2,4-dimethyl-1H-pyrrole-3- carboxylic acid 253870-02-9
9 Ibrutinib Ibrutinib N-1 1022150-11-3
3-(4-Phenoxy Phenyl)-1H-pyrazole [3,4-d] pyrimidin-4-Amine 330786-24-8
10 Lapatinib N-[3-Chloro-4-(3- fluorobenzyloxy)phenyl]-6- iodoquinazolin-4-amine 231278-20-9
11 Pemetrexed Diethyl L-glutamate hydrochloride 1118-89-4
2-Chloro-4,6-dimethoxy-1,3,5-triazine 3140-73-6
4-[2-(2-Amino-4,7-dihydro-4-oxo-3H- pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid (EBA) 137281-39-1
12 Bendamustin HCL 1-Methyl-5-amino-1H-benzimidazole-2- butanoic acid ethyl ester 3543-73-5
13 Irinotecan 1-Chlorocarbonyl-4-piperidinopiperidine hydrochloride 143254-82-4
14 Lenalidomide 3-(4-nitro-1-oxo-1, 3-dihydrosoindol-2-yl, piperidine-2, 6-dione 827026-45-9
2-(Bromomethyl)-3-Nitrobenzoic Acid Methyl Ester 98475-07-1
3-Aminopiperidine-2,6-dione Hydrochloride 24666-56-6
2-Methyl-3-nitrobenzoic Acid 1975-50-4
3-Amino 2-Methyl Benzoic Acid 52130-17-3
15 Temozolomide 5-Amino-N1-methyl-1H-imidazole-1,4 – dicarboxamide 188612-53-5
16 Temozolomide / Dacarbazine 5-Amino-4-imidazolecarboxamide Hydrochloride 72-40-2
17 Letrazole 4-(1H-1,2,4 Trizole-1-ylmethyl) Benzonitrile (N-1) 112809-25-3
18 Zoledronic Acid Imadazole acetic acid Hcl 3251-69-2
19 Cytarabine Cyclocytidine HCL 10212-25-6
20 Methotrexate L-Glutamic acid diethyl ester hydrochloride 1118-89-4
2,4,5,6-Tetraaminopyrimidine sulfate 5392-28-9
4-(Methylamino)benzoic Acid 10541-83-0
2,4-Diamino-6-(hydroxymethyl)petridine 945-24-4
6-(Chloromethyl)pteridine-2,4-diamine monohydrochloride 82778-08-3
N-[4-(Methylamino)benzoyl]-L-glutamic acid zinc salt 66104-81-2
Methotrexate Disodium salt (Crude) 7413-34-5
21 Abiraterone 17 iodo andrasta 5,16, dien3b-Ol (Abiraterone Base) 154229-19-3
22 Melphalan Ethyl Ester of N-Phthaloyl P-Amino-Lphenylalanine 74743-23-0
23 Chlorambucil P-Amino Phenyl Butyric Acid 15118-60-2
24 Lomustine 1-(2-chloroethyl) 3-cyclo Hexyl nitroso urea 13010-47-4
GENERAL INTERMEDIATES
1 Vonoprazan 5-(2-Fluorophenyl)-1H-pyrrole-3- carbaldehyde (Main Chain) 881674-56-2
Pyridine-3-sulfonyl chloride hydrochloride (Side Chain) 16133-25-8
5-(2-fluorophenyl)-1-(pyridin-3- ylsulfonyl)-1H-pyrrole-3-carbonitrile 881677-11-8
2 Ropivacaine (2S)-N-(2,6-Dimethylphenyl)-2- piperidinecarboxamide (N-1) 27262-40-4
3 Vecuronium Bromide 2 16-dipiperidin-1-ylandrosta-3 17-diol 13522-6-2
4 Tranexamic Acid 4-(Aminomethyl)benzoic Acid 56-91-7
5 Modafinil 2[(Diphenylmethyl)thio]acetic Acid, 63547-22-8
6 Neostigmine Methylsulfate &  Neostigmine Bromide 3-Dimethylaminophenol (DMAP) 99-07-0
7 Suxamethonium Chloride Succinyl Chloride 543-20-4
8 Cinnarzine & Funnarzine Cinnamyl alcohol 104-54-1